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What are the treatments for mouth ulcers?

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Oral ulcers—also known as aphthous ulcers or canker sores—are common, painful, shallow mucosal lesions that typically appear on non-keratinized oral surfaces such as the inner lips, cheeks, tongue, floor of the mouth, or soft palate. They are usually self-limiting, resolving within 7–14 days without scarring in most cases. Management focuses on symptom relief, accelerating healing, and preventing recurrence where appropriate.

First-line supportive measures include maintaining excellent oral hygiene with a soft-bristled toothbrush and avoiding irritants such as sodium lauryl sulfate (SLS)-containing toothpastes, spicy or acidic foods, and mechanical trauma. Topical therapies are often effective: over-the-counter options include protective pastes (e.g., Orabase) or analgesic gels containing benzocaine or lidocaine for temporary pain relief. For moderate-to-severe ulcers, prescription-strength topical corticosteroids—such as triamcinolone acetonide 0.1% dental paste or fluocinonide 0.05% gel—applied several times daily can significantly reduce inflammation and healing time.

In recurrent or persistent cases—especially those associated with systemic conditions like celiac disease, inflammatory bowel disease, Behçet’s syndrome, or nutritional deficiencies (e.g., iron, folate, vitamin B12, or zinc)—a thorough clinical evaluation is essential. Laboratory testing may be warranted to identify underlying contributors. Systemic interventions, including short-course oral corticosteroids or immunomodulators, are reserved for severe, refractory, or syndromic presentations and should be managed by a specialist (e.g., oral medicine physician, dermatologist, or gastroenterologist).

While no universally effective preventive strategy exists, evidence suggests that stress reduction, consistent sleep hygiene, balanced nutrition, and avoidance of known dietary triggers may help reduce frequency in susceptible individuals. Patients with frequent, large, or unusually persistent ulcers—or those accompanied by systemic symptoms such as fever, weight loss, or genital ulcers—should seek prompt medical evaluation to exclude serious underlying pathology.

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