T-cell receptor gene rearrangement test
Health Checkups
estimated about CNY 1000-2000
(estimated about USD 150-300)
7 day
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Description
The T-cell receptor gene rearrangement test helps diagnose T-cell lymphoproliferative disorders and confirm clonality in suspected lymphomas, with ChinaMedicalHub coordinating hospital booking and interpreter support for patients in China at a reference cost of ¥1,000–¥2,000.
Main Uses
The primary purpose of T-cell receptor gene rearrangement testing is to identify and diagnose T-cell neoplasms, including T-cell lymphomas and leukemias. It is also used to monitor treatment response and detect minimal residual disease in patients with known T-cell malignancies. This test is applicable in scenarios where there is suspicion of a T-cell derived hematologic malignancy based on clinical presentation, histopathology, or other laboratory findings.
Normal Range
The normal range for T-cell receptor (TCR) gene rearrangement testing is typically characterized by a polyclonal pattern, indicating a diverse T-cell population. There are no specific numerical values; instead, the absence of a dominant clone or monoclonal pattern is considered normal.
Low Values - Possible Causes
A low value, or lack of detectable TCR gene rearrangements, can be caused by: 1. Insufficient sample quality, 2. Early stage of disease where clonality is not yet established, 3. Non-T cell malignancies, 4. Immunosuppressive conditions, 5. Technical issues with the test procedure.
High Values - Possible Causes
A high value, or detection of a monoclonal TCR gene rearrangement, can be caused by: 1. T-cell lymphoma, 2. Chronic lymphoproliferative disorders, 3. Post-transplant lymphoproliferative disorder, 4. Sezary syndrome, 5. Lymphocyte-rich Hodgkin's lymphoma.
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