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Non-invasive skin barrier function assessment

Dermatology & Aesthetics estimated about CNY 400-900

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Description

A clinical procedure measuring transepidermal water loss (TEWL), skin surface pH, and stratum corneum hydration to objectively evaluate epidermal barrier integrity and function.

Main Uses

Primary purposes include objective assessment of skin barrier integrity and functional status; monitoring disease activity and treatment response in inflammatory dermatoses (e.g., atopic dermatitis, rosacea, psoriasis); evaluating cosmetic product efficacy (moisturizers, barrier-repair formulations); guiding personalized skincare regimens; pre- and post-procedural skin evaluation in aesthetic dermatology; and clinical research on skin physiology and toxicology.

Normal Range

Transepidermal Water Loss (TEWL): 5–30 g/m²/h (varies by anatomical site, age, and environmental conditions); Skin Surface pH: 4.1–5.8 (typically 4.7–5.5 on healthy facial/forearm skin); Stratum Corneum Hydration (Water Content): 25–75 AU (arbitrary units; device-dependent, e.g., Courage+Khazaka CM 825 or MoistureMeter SC), with optimal range ~40–60 AU for normal adult facial skin.

Low Values - Possible Causes

1. Over-hydration or occlusion (e.g., prolonged use of occlusive ointments or plastic wrap); 2. Severe epidermal hyperplasia (e.g., chronic psoriasis plaques with thickened stratum corneum reducing water flux); 3. Technical artifact (e.g., improper probe placement, low ambient humidity, cold skin surface, or device calibration error); 4. Advanced age with reduced baseline TEWL in some individuals; 5. Use of highly astringent or alcohol-based products causing transient surface dehydration masking true hydration.

High Values - Possible Causes

1. Compromised skin barrier integrity (e.g., atopic dermatitis, contact dermatitis, irritant-induced damage); 2. Environmental stressors (low humidity, cold/dry air, UV radiation exposure); 3. Over-exfoliation (chemical or physical) or excessive cleansing disrupting lipid matrix; 4. Post-procedure inflammation (e.g., after laser resurfacing, chemical peels, or microneedling); 5. Xerosis, ichthyosis, or other inherited or acquired disorders of keratinization and lipid synthesis.

non-invasive skin barrier test TEWL measurement skin hydration and pH test

estimated about CNY 400-900